Is kynurenine a novel and important vasodilator in human septic shock?
نویسندگان
چکیده
Materials and methods Patients (n = 16) with septic shock had IDO activity assessed (expressed as the ratio of Kyn to Trp) and the severity of their hypotension determined (expressed by inotrope requirement) during the course of illness. Normal and blood pressure-matched controls were also studied. Septic shock was induced in wild type and IDO-/mice, and the effect of 1-methyl-tryptophan (1 MT, a competitive inhibitor of IDO) on blood pressure was determined. In animal studies, IDO expression and activity was assessed by IHC in resistance vessels and plasma Kyn, respectively. The direct vascular effect of Trp and Kyn was determined by vessel functional studies on mouse aortic rings.
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